Human Peripheral B Cell Subsets: Evolving notions about B cell biology and the broad relevance of B cells in disease.

Authors

Shiv Pillai, Elif Çakan, Anson Hui

Published in

Immunological reviews. Volume 342. Issue 1. Pages e70177.

Abstract

This review will focus on some aspects of the biology of human peripheral B cells and how this biology might inform us as to why these cells are important therapeutic targets. Transitional B cells and the alterations in metabolism in transitional B cells as they mature may be relevant to the induction of B cell tolerance. The human extrafollicular B cell response and the activated B cell subsets that emerge both in extrafollicular responses as well as in germinal center responses will be discussed. The relatively transient nature of activated B cells in contrast to durable memory B cells will be considered and the review will also discuss how durable responses are generated both by extrafollicular responses as well as by germinal center responses.

PMID:
42740428
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

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