P(NIPAM-co-DMAEMA) hydrogel engineering of magnetic nanodiscs for smart delivery of viral vectors under magnetic stimulation.

Authors

Micaela A Macchione, P Rafael Donnarumma, Firas Hamdan, Ivan Budić, Eduart Gutiérrez-Pineda, Elif Kocar, Tomislav Marković, Vincenzo Cerullo, Danijela Gregurec, Sergio E Moya

Published in

Chemical communications (Cambridge, England). Sep 15, 2026. Epub Sep 15, 2026.

Abstract

Magnetic nanodiscs (MNDs) act as nanoscale heaters under high magnetic fields. Here, MNDs were coated with the positively charged thermoresponsive polymer poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (P(NIPAM-co-DMAEMA) and evaluated for adenovirus complexation and magnetothermal release, enabling viral delivery by remote regulation of transfection through thermal modulation of electrostatic interactions.

PMID:
42740592
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

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