Authors
Gustavo I Centeno-Saenz, Robinson Robles-Hernández, Alejandra Ramírez-Venegas, Sandra P Guinto-Ramirez, Rafael Hernández-Zenteno, Francisco López-Montiel, Abraham Tolentino-de la Mora, Justino Regalado, Rogelio Perez-Padilla
Published in
Respiratory research & clinical practice. Volume 52. Issue 3. Pages e20250271. Epub Aug 13, 2026.
Abstract
To compare the survival rates for two cohorts of COPD patients living in Mexico City and studied 20 years apart at the same referral center, with demographic characteristics, lung function, hypoxemia, type of exposure associated with COPD, and socioeconomic status being analyzed.
Two cohorts of COPD patients were studied and followed at a single referral center for respiratory diseases in Mexico City, at an altitude of 2,240 m above sea level. The first cohort was studied between 1996 and 2003, and the second was studied between 2016 and 2023. Participants were followed for seven years, and a multivariate Cox model was used in order to analyze survival.
The first cohort included 434 patients, and the second comprised 416 patients, with a total of 850 patients being analyzed. Of those, 68% had COPD from tobacco smoking and 32% had COPD from biomass smoke exposure. In the multivariate Cox model adjusted for age, sex, smoking status, exposure to biomass smoke, BMI < 21 kg/m2, hypoxemia, six-minute walk distance, and lung function as assessed by spirometry, the 2016-2023 cohort showed a significant reduction in the seven-year mortality rate (hazard ratio = 0.59; 95% CI, 0.44-0.81; p = 0.001) when compared with the 1996-2003 cohort.
Survival of COPD patients has improved over the past 20 years after accounting for several mortality predictors.
PMID:
42740886
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.
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