[Analysis of the global disease burden of cervical cancer in women aged 65 years and older based on the global burden of disease database].

Authors

X H Yuan, Y Chen, Z Y Kuang, L Y Fang, Y Wang, Y Xie, Y H Fang, R X Wang, B L Sui, Y Zhang

Published in

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. Volume 60. Issue 9. Pages 1436-1446. Sep 06, 2026.

Abstract

Objective: Based on the Global Burden of Disease (GBD) database, this study analyzed the disease burden and attributable risk factors of cervical cancer among women aged 65 years and older globally from 1990 to 2021, and explored its association with the Socio-demographic Index (SDI) as well as age-specific distribution characteristics. Methods: This ecological study utilized the GBD database to extract data on the number of incident cases, age-standardized incidence rate (ASIR), number of deaths, age-standardized mortality rate (ASMR), disability-adjusted life years (DALY), age-standardized DALY rate (ASDR), and risk factor-attributable burden for cervical cancer in women aged ≥65 years from 1990 to 2021. The average annual percent change (AAPC) was calculated using Joinpoint regression analysis. Spearman rank correlation analysis was employed to assess the association between ASIR, ASDR, and SDI. Locally weighted regression (LOESS) was applied to fit smooth curves to illustrate expected trends across different SDI levels. Results: From 1990 to 2021, the ASIR of cervical cancer among older women decreased from 41.23/100 000 (95%UI: 37.71/100 000-44.45/100 000) to 32.43/100 000 (95%UI: 28.61/100 000-35.57/100 000) [AAPC:-0.8(95%CI:-0.9 to -0.6)]. The ASMR declined from 35.45/100 000 (95%UI: 32.24/100 000-38.54/100 000) to 25.20/100 000 (95%UI: 22.23/100 000-27.62/100 000) [AAPC:-1.1(95%CI:-1.2 to -1.0)]. The ASDR decreased from 658.01/100 000 (95%UI: 602.42/100 000-714.72/100 000) to 467.29/100 000 (95%UI: 416.92/100 000-510.34/100 000) [AAPC:-1.1(95%CI:-1.2 to -0.9)]. A negative correlation was observed between cervical cancer burden and SDI globally and across the 21 GBD regions (r=-0.881 4, P<0.001), with a greater burden in regions with lower SDI among the 204 countries and territories (r=-0.713 4, P<0.001). The number of incident cases, deaths, and DALYs in the 65-69 and 70-74 age groups accounted for 64.82%, 56.22%, and 68.96% of the total for women aged ≥65 years, respectively. The attributable risk burden from smoking [AAPC:-2.1(95%CI:-2.2 to -2.0)] and high-risk sexual behavior [AAPC:-1.1(95%CI:-1.2 to -0.9)] both decreased over time, this declining trend in attributable risk burden for smoking and high-risk sexual behavior was also observed with increasing age. Conclusions: Population aging has contributed to an increase in the absolute burden of cervical cancer among older women, with those aged 65-74 years identified as a key population requiring attention. Expanding the coverage and age range of screening programs is essential for further reducing the the burden of cervical cancer.

PMID:
42736147
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

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