Trends and Disparities in Aspiration Pneumonitis Mortality With Co-Listed Stroke Among US Adults, 1999-2024: A CDC WONDER Analysis.

Authors

Mirza Ammar Arshad, Shiza Talib Butt, Wahhaj Munir, Muhammad Hassan Daniyal, Rohan Ahmad Daud, Warda Ikram, Rijas Ramish, Isbah Aman, Maryam Aslam, Hafiz Ahmad Masood, Asad Ali Ahmed Cheema

Published in

Brain and behavior. Volume 16. Issue 9. Pages e71739.

Abstract

Aspiration pneumonitis is a serious poststroke respiratory complication, yet contemporary US mortality trends involving aspiration pneumonitis as the underlying cause of death with co-listed stroke remain unclear. We evaluated national trends and disparities in aspiration pneumonitis mortality with co-listed stroke among US adults aged ≥ 25 years from 1999 to 2024.
We conducted a retrospective, population-based serial cross-sectional analysis of CDC WONDER multiple cause of death data from 1999 through 2024. Deaths were included when aspiration pneumonitis (ICD-10 J69.0) was the underlying cause and stroke (I60-I69) was a contributing cause among adults aged ≥ 25 years. Age-adjusted mortality rates (AAMRs) per 100,000 population were standardized to the 2000 US population; age-specific rates were crude. Joinpoint regression estimated annual percent changes (APCs) and average annual percent changes (AAPCs).
A total of 296,691 deaths were identified. The overall AAMR declined from 9.20 in 1999 to 3.55 in 2024 (AAPC, -3.66%; 95% CI, -4.34 to -2.97, p < 0.001). Mortality declined among men from 13.38 to 4.92 (AAPC, -3.85%) and women from 6.79 to 2.46 (AAPC, -3.92%; both p < 0.001). Mortality declined across all census regions, including Northeast (AAPC, -3.98%; p < 0.001), Midwest (AAPC, -3.76%; p < 0.001), South (AAPC, -3.93%; p < 0.001), and West (AAPC, -3.57%; p < 0.001), with the South having the higher AAMR (3.88) in 2024. Mortality remained higher in nonmetropolitan counties, with AAMR declining from 9.96 in 1999 to 4.42 in 2020 (AAPC, -4.05%; p < 0.001), compared with metropolitan counties, where the AAMR declined from 9.02 to 3.80 (AAPC, -4.31%; p < 0.001). Among non-Hispanic Black adults, the 2014-2024 trend was stable (APC, 1.13%; p = 0.12). Rates increased after 2010 among adults aged 35-44 years (APC, 6.65%; p < 0.001), 45-54 years (APC, 4.70%; p < 0.001), and 55-64 years (APC, 3.96%; p < 0.001).
Aspiration pneumonitis mortality with co-listed stroke declined nationally, but progress was uneven, with persistent demographic, regional, and rural disparities.

PMID:
42740601
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.