A clinically-oriented foundation model for intraoperative pathology.

Authors

Zihan Zhao, Fengtao Zhou, Ronggang Li, Bing Chu, Xinke Zhang, Xueyi Zheng, Ke Zheng, Xiaobo Wen, Jiabo Ma, Yihui Wang, Jiewei Chen, Chengyou Zheng, Jiangyu Zhang, Yongqin Wen, Jiajia Meng, Ziqi Zeng, Xiaoqing Li, Jing Li, Dan Xie, Yaping Ye, Yu Wang, Hao Chen, Muyan Cai

Published in

Nature medicine. Sep 10, 2026. Epub Sep 10, 2026.

Abstract

Intraoperative pathology is pivotal to precision surgery, yet its clinical impact is constrained by diagnostic complexity and the limited availability of high-quality frozen-section data. While computational pathology has made significant strides, the lack of large-scale, prospective validation has impeded its routine adoption in surgical workflows. Here, we introduce CRISP, a clinically oriented foundation model developed on over 100,000 frozen sections from ten medical centers, specifically designed to provide Clinically-oriented Robust Intraoperative Support for Pathology (CRISP). CRISP was comprehensively evaluated on more than 15,000 intraoperative slides across nearly 100 retrospective diagnostic tasks, including benign-malignant discrimination, key intraoperative decision-making, and pan-cancer detection, etc. The model demonstrated robust generalization across 6 institutions, 14 tumor types, and 24 anatomical sites-including previously unseen sites and rare cancers. In a prospective cohort of over 3,000 patients, CRISP sustained high diagnostic accuracy under real-world conditions, directly informing surgical decisions in 92.6% of cases. Human-AI collaboration further reduced diagnostic workload by 35%, avoided 105 ancillary tests and enhanced detection of micrometastases with 87.5% accuracy. Together, these findings suggest that CRISP represents a clinically oriented approach to AI-driven intraoperative pathology, with the potential to support surgical decision-making and facilitate the translation of computational methods into clinical practice.

PMID:
42742185
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.