Authors
Li Ding, Jing Huang, Kai Feng, Huangzhipeng Wu, Shu Chen, Zipeng Zhang, Haixin Wang, Jin Wang, Sheng Chen, Qingchen Shen, Yuyue Zhong
Published in
Small (Weinheim an der Bergstrasse, Germany). Pages e75552. Sep 15, 2026. Epub Sep 15, 2026.
Abstract
Chronic inflammation and inflammation-associated local microenvironmental imbalance are critical barriers to effective wound healing, while conventional dressings remain functionally limited. Here, we developed a drug-loaded passive cooling nanocomposite hydrogel that can simultaneously regulate the physical temperature and biochemical wound microenvironment. The hydrogel is constructed from a poly(vinyl alcohol)-sorbitol network incorporating sulfated cellulose nanocrystals, silica nanoparticles, and salidroside, a potent anti-inflammatory phytochemical, achieving both exceptional passive cooling with a temperature drop of 6.2°C compared to non-covered control under sunlight and the sustained release of salidroside. In vitro, the hydrogel exhibits time-dependent antibacterial efficacy over 97% bacterial inhibition and effectively suppresses inflammation. In a murine full-thickness wound model, the hydrogel promoted local cooling and accelerated wound closure, achieving near-complete healing by day 11, earlier than the phosphate-buffered saline control. Histological analyses confirm attenuated inflammation and enhanced tissue remodeling, as evidenced by suppressed TNF-α expression and CD68 macrophage infiltration, increased α-SMA myofibroblasts, and organized collagen deposition. This work introduces a cooling-and-curing strategy, where material enables physical cooling and localized drug delivery to operate synergistically to disrupt the inflammatory cycle, offering a transformative platform for intelligent wound management.
PMID:
42742102
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.
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