Authors
Wan Nur Izzati Wan Azhan, Fatin Nadzirah Zakaria, Danial Akmal Fuad Al' Arifin, Nur-Zulaikha Amlie, Evana Kamarudin, Faheze Paiman, Rio Risandiansyah, Razif Dasiman
Published in
Annali dell'Istituto superiore di sanita. Volume 62. Issue 3. Pages 267-276.
Abstract
Bisphenol S (BPS) is a widespread BPA substitute with emerging immunotoxicity; this review synthesizes zebrafish and rodent experimental evidence to clarify BPS-induced inflammation.
Narrative synthesis of experimental studies in zebrafish and rodent models, focusing on molecular pathways, organ-level effects, and exposure timing.
Across models, BPS consistently activates an oxidative stress-mediated NF-κB axis with increased ROS, lipid peroxidation, and upregulation of TNF-α, IL-1β, and IL-6; chronic and developmental low-to-moderate exposures produced stronger inflammatory phenotypes than acute high doses.
Convergent mechanistic and pathological findings strengthen the weight of evidence for BPS immunotoxicity and support targeted monitoring and controls; key research gaps include inflammasome activation, receptor mechanisms, sex differences, mixture effects, epigenetic regulation, and standardization.
PMID:
42742244
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 6
- Comments 0