Serum N-terminal pro-B-type natriuretic peptide and physical performance in middle-aged and older patients with chronic kidney disease.

Authors

Riri Kobayashi, Shoya Mori, Shun Yoshikoshi, Masahiro Matsui, Chie Saito, Seiji Maeda, Makoto Kuro-O, Kunihiro Yamagata, Keisei Kosaki

Published in

Journal of nephrology. Sep 15, 2026. Epub Sep 15, 2026.

Abstract

Observational studies have reported that impaired physical performance is associated with an elevated risk for cardiovascular disease (CVD) in patients with non-dialysis chronic kidney disease (CKD). However, there is limited evidence supporting this finding from a pathological perspective. As such, the present study aimed to determine the association between physical performance variables and serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, a biomarker for estimating CVD risk, in patients with non-dialysis CKD.
This cross-sectional study involved 113 middle-aged and older patients with CKD (mean [ ± SD] age, 66 ± 9 years; 50.4% women). We evaluated serum NT-proBNP levels, handgrip strength, knee extension strength, 30-second chair stand test, maximal gait speed, 60-second single-leg stance test, and sit-and-reach tests.
Decreased handgrip strength, knee extension strength, and 60-second single-leg stance score were associated with elevated serum NT-proBNP levels after adjusting for age, sex, hypertension, diabetes, dyslipidemia, body mass index, urinary albumin-to-creatinine ratio, estimated glomerular filtration rate, medication use (ie, diuretic use, β-blocker use, renin-angiotensin system inhibitor use), and physical activity level (all P < .05). Moreover, stepwise regression analysis revealed that the score for completion of the 60-second single-leg stance test was selected as a covariate of serum NT-proBNP levels, even after adjusting for muscle strength variable.
Results of this study suggest that attenuated muscle strength and balance function tend to be associated with higher serum NT-proBNP levels in patients with non-dialysis CKD, which expands previous observational findings.

PMID:
42742153
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

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