Norrin Treatment Prevents Vascular Permeability and Neural Cell Loss While Preserving Vision in Diabetic Rats.

Authors

Laura González-González, Alyssa Dreffs, Cheng-Mao Lin, Xuwen Liu, Ethan Hendry, David A Antonetti

Published in

Diabetes. Sep 15, 2026. Epub Sep 15, 2026.

Abstract

We investigated whether norrin treatment can prevent or reverse diabetes-induced visual dysfunction in rats. Norrin treatment preserved visual acuity and contrast sensitivity, reduced neural cell death, inflammation, and vascular permeability, and restored inflammation-related gene expression patterns in diabetic retinas. Our results support targeting the norrin signaling pathway as a potential therapy for maintaining blood-brain barrier properties and preventing vision loss due to diabetes.

PMID:
42743087
Bibliographic data and abstract were imported from PubMed on 16 Sep 2026.

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