Viral hijacking of the host ubiquitin-proteasome system for immune escape.

Authors

Junji Zhu, Michaela U Gack

Published in

Science signaling. Volume 19. Issue 955. Pages eaek8777. Sep 15, 2026. Epub Sep 15, 2026.

Abstract

E3 ubiquitin ligases regulate protein turnover and signaling by mediating degradative or nondegradative types of ubiquitylation. In the 20 August 2026 issue of Science, Glassman et al. identified mechanisms by which viral proteins commandeer the ubiquitin-proteasome system to dysregulate innate immunity, unveiling potential avenues for designing antiviral interventions.

PMID:
42743266
Bibliographic data and abstract were imported from PubMed on 16 Sep 2026.

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