Longitudinal Outcomes of Fetuses with an Isolated Narrow Cavum Septi Pellucidi: Prenatal Diagnosis to Early Childhood Neurodevelopment Assessment.

Authors

Anju Bhatia, Maegan Yingrui Ng, Si Hui Chu, June Vk Tan, Suresh Chandran

Published in

Fetal diagnosis and therapy. Pages 1. Sep 15, 2026. Epub Sep 15, 2026.

Abstract

To evaluate prenatal and postnatal immediate and long-term outcomes of fetuses with an isolated narrow cavum septi pellucidi(CSP).
Single-centre retrospective review of a cohort of fetuses with an isolated narrow CSP (below -2 standard deviations [SD] for gestational age [GA]) identified on mid-trimester anomaly scan from 2017-2022.
During 6 years, 77546 pregnant women underwent anomaly scan, and 228 were identified with an isolated narrow CSP. A follow-up ultrasound at a mean GA of 28.9 weeks showed that CSP measurements were normalized in 58.5% of cases, while in the remaining cases, they were below -2 SD for the respective GA. There were no additional cerebral findings; however, three fetuses were growth-restricted. Among these, 130 mothers delivered at our institution, at a mean GA of 38.3 weeks, and were followed for perinatal and long-term neurodevelopmental outcomes. Clinical examination at birth was unremarkable for all neonates. For the majority of them (n=105/130), cranial scan at one month was normal, and minor findings were noted in 18 cases. Neurodevelopmental outcomes were normal for 81.5% (n=106) of infants at 2 years, while 24 (18.5%) were referred to the Child Development Unit with concerns regarding speech and language delay, behavioral issues, gross motor delay, and global developmental delay. Extended follow-up showed normal outcomes for 89.2%(n=116) of cases; nine of 15 children with speech-language delay had improved, while five (3.85%) were diagnosed with autism spectrum disorder.
An isolated narrow CSP is a benign, transitory, subtle anatomical finding in the prenatal brain. However, its identification should prompt detailed neuroimaging and evaluation to exclude associated abnormalities. The long-term neurodevelopmental outcome is overall good when the finding is isolated.

PMID:
42743083
Bibliographic data and abstract were imported from PubMed on 16 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.