Diagnosis of Mucormycosis: Current Situation, Challenges and Future Prospects.

Authors

Yixuan Qu, Yuling Xiao, Lina Liu, Junyan Qu

Published in

Mycoses. Volume 69. Issue 4. Pages e70175.

Abstract

Mucormycosis, an aggressive fungal infection caused by members of the order Mucorales, progresses rapidly and is associated with high mortality, particularly in immunocompromised hosts such as patients with uncontrolled diabetes, transplant recipients or those with COVID-19-associated immunosuppression. Early diagnosis remains challenging with current clinical methods, yet it is essential to reduce mortality. This review examines the evolution of diagnostic strategies for mucormycosis, ranging from conventional techniques such as histopathology, culture and microscopy to advanced and emerging methods including molecular assays, serological testing, imaging and metabolomics. We also explore the ongoing transition towards integrated, rapid and non-invasive diagnostic platforms that leverage novel biomarkers, portable devices and artificial intelligence. These new technologies have the potential to facilitate early diagnosis, thereby enabling early treatment and reducing the mortality rate of mucormycosis.

PMID:
41983640
Bibliographic data and abstract were imported from PubMed on 16 Sep 2026.

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