Authors
Jorge Luis Vargas-Navarro, Joaquín Alberto Padilla-Flores, Juan Carlos Granados-Rivas, Luis Antonio Aguilar-Torres, Sagiv Ali Gregori-Fattel, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez
Published in
The international journal of biochemistry & cell biology. Pages 107029. Sep 15, 2026. Epub Sep 15, 2026.
Abstract
The tumor suppressor protein p53 is an often-mutated transcriptional factor in metastatic malignancies. The mutations result in the protein acquiring new oncogenic capabilities and/or losing canonical suppressor functions, either way contributing to cancer growth and resistance to conventional radio- and chemo-therapy. In addition, p53 mutations are linked to processes involved in tumor proliferation and metastasis, as well as in the regulation of redox (prooxidant/antioxidant) metabolism. The present review examines the regulatory role of different p53 mutations on redox metabolism within metastatic tumor cells, aiming to elucidate whether redox metabolism may be a suitable biomarker and promising drug target for novel therapeutic strategies.
PMID:
42744218
Bibliographic data and abstract were imported from PubMed on 16 Sep 2026.
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