Authors
Yu-Chien Lin, Kuo-Liong Chien, Hung-Ju Lin, Ta-Chen Su, Jui Wang, CARES Study Group
Published in
Journal of sleep research. Pages e70458. Sep 15, 2026. Epub Sep 15, 2026.
Abstract
The study investigated the association between sleep duration and the risks of all-cause and cardiovascular death, and elucidated the mediating role of atherosclerotic markers in these associations to identify potential biological pathways. We used data from the Chin-Shan Community Cardiovascular Cohort in Taiwan, a prospective study. After excluding individuals with incomplete data and those with cardiovascular diseases, 3305 participants were included. Participants were classified into three sleep duration groups as short (≤ 6 h), normal (7-8 h) and long (≥ 9 h) through structured questionnaires. Cox proportional hazard models and restricted cubic splines assessed the associations and non-linear trends. Causal mediation analysis was performed to identify potential mediators. During a median of 30.8 years of follow-up, after adjusting for potential confounding factors, long sleep duration was significantly associated with increased risks of all-cause mortality (adjusted hazard ratio: 1.17, 95% confidence interval: 1.01, 1.35), while short sleep duration showed no significant difference. Long sleep duration was not significantly associated with cardiovascular mortality (adjusted hazard ratio: 1.18, 95% confidence interval: 0.89, 1.56). Short sleep duration showed no significant association with either outcome. No significant interactions were found in sub-group analyses by age, sex, body mass index, hypertension and diabetes. This study found that longer sleep duration increases the risk of all-cause mortality, which may be partially mediated by systolic blood pressure.
PMID:
42744622
Bibliographic data and abstract were imported from PubMed on 16 Sep 2026.
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