Case Report: Near-complete resolution of nail psoriasis with upadacitinib in a pediatric patient.

Authors

Yulin Huang, Sijian Wen

Published in

Frontiers in immunology. Volume 17. Pages 1941127. Epub Sep 01, 2026.

Abstract

Nail psoriasis (NP) is refractory in children, causing punctate pits, onycholysis, subungual hyperkeratosis and discoloration, impairing quality of life. We report a 14-year-old boy with 4-year NP, all fingernails involved with no cutaneous lesion, and unresponsive to traditional therapy. After 20-week oral upadacitinib, all nail lesions achieved near-complete resolution with only minimal residual nail changes, and no treatment-related adverse events. This suggests that upadacitinib demonstrates favorable efficacy and safety for pediatric refractory NP, large-scale prospective clinical investigation are warranted to validate our findings.

PMID:
42745747
Bibliographic data and abstract were imported from PubMed on 16 Sep 2026.

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