Authors
Masaya Yanagi, Shizuka Ishida, Osamu Shirakawa, Mamoru Hashimoto
Published in
Frontiers in psychiatry. Volume 17. Pages 1879294. Epub Sep 01, 2026.
Abstract
Impaired gamma-band neural synchrony has emerged as a promising biomarker for precision psychiatry; however, clinically scalable methods for individual-level assessment remain limited. Widely available evoked response audiometry (ERA) systems offer a pragmatic and accessible platform for measuring the 40-Hz auditory steady-state response (ASSR), and their utility has been demonstrated in patients with schizophrenia. This study investigated whether ERA-based profiling could be extended to mood disorders, which are believed to share underlying biological mechanisms with schizophrenia.
Using a conventional ERA system, phase delay and phase-locking status of the 40-Hz ASSR were assessed in 107 participants, including individuals with schizophrenia (n = 29), bipolar disorder (n = 24), major depressive disorder (n = 25), and healthy controls (n = 29). Phase locking status was classified as either a phase-locked response or a nonphase-locked response (NPLR).
Compared with the healthy control group, all clinical groups exhibited significant phase delays in the 40-Hz ASSR. Phase-locking analysis identified NPLR not only in individuals with schizophrenia but also in a subset of participants with bipolar disorder and major depressive disorder.
These findings extend previous evidence of 40-Hz ASSR phase delay and demonstrate that individual-level NPLR assessment using a conventional ERA system applies beyond schizophrenia to bipolar disorder and major depressive disorder. ERA-based evaluation of the 40-Hz ASSR may represent a practical and scalable approach for biomarker development in mood and psychotic disorders.
PMID:
42745834
Bibliographic data and abstract were imported from PubMed on 16 Sep 2026.
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