Sortilin Immunoreactivity Is Associated with Lymphatic and Extrathyroidal Invasion in Medullary Thyroid Carcinoma: A Preliminary Single-Center Study.

Authors

Emre Gezer, Seda Duman Öztürk, Aslı Bala Öcal, Alev Selek, Zeynep Cantürk, Berrin Çetinarslan, Mehmet Sözen

Published in

Endocrine research. Pages 1-7. Sep 16, 2026. Epub Sep 16, 2026.

Abstract

Medullary thyroid carcinoma (MTC) is a rare aggressive thyroid malignancy lacking reliable molecular markers. Sortilin is associated with tumor invasiveness in several cancers, but its role in MTC remains unclear.
Sortilin immunoreactivity was retrospectively evaluated by immunohistochemistry using both staining percentage and H-score in tumor samples from 24 patients who underwent total thyroidectomy for MTC.
All tumors showed sortilin positivity. Higher staining percentage was significantly associated with lymphatic invasion (p = 0.002) and extrathyroidal extension (p = 0.024), whereas the corresponding H-score comparisons did not reach statistical significance (p = 0.106 and p = 0.160, respectively).
In this preliminary single-center cohort, sortilin staining percentage, but not H-score, was associated with locally invasive histological features. These findings are hypothesis-generating and do not establish sortilin as an independent prognostic biomarker.

PMID:
42747799
Bibliographic data and abstract were imported from PubMed on 17 Sep 2026.

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