Timing and trajectory of acute kidney injury predict mortality in alcohol-associated hepatitis: A multinational cohort study.

Authors

Butros Fakhoury, Ali Khan, Pojsakorn Danpanichkul, Omar Albhaisi, Kriti Soni, Ximena Parraga, Francisco Idalsoaga, Arun Valsan, Gowripriya Nair, Jorge Arnold, María Ayala-Valverde, Carolina Ramirez-Cadiz, Juan Pablo Roblero, Daniela Simian, José Antonio Velarde-Ruiz Velasco, Jacqueline Córdova, Manuel Mendizabal, Sebastián Marciano, Kristina R Chacko, Lubomir Skladaný, Michał Kukla, Arun J Sanyal, Vijay H Shah, Patrick S Kamath, Marco Arrese, Winston Dunn, Ashwani K Singal, Ramon Bataller, Luis Antonio Díaz, Juan Pablo Arab

Published in

Hepatology communications. Volume 10. Issue 10. Oct 01, 2026. Epub Sep 16, 2026.

Abstract

Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear.
In this prospective multicenter cohort from the Global AlcHep Prospective Database, patients with AH were classified as no AKI, prevalent AKI at admission, or incident AKI during hospitalization. The primary outcome was 90-day mortality, using competing-risks regression with liver transplantation as the competing event. A 7-day landmark analysis assessed the prognostic impact of AKI trajectory among prevalent AKI patients.
Among 581 patients, 37% had prevalent AKI, and 11% developed incident AKI. The 90-day mortality was 18.2% (11 transplantations, 1.9%). Prevalent AKI was predominantly functional (84%), while incident AKI had a higher proportion of structural injury (44%). Despite lower baseline severity [median mDF 59.8 vs. 69.3 and lower rates of ACLF grade 3 (23.4% vs. 45.3%)], incident AKI conferred mortality of similar magnitude to prevalent AKI (sHR 2.18, 95% CI 1.19-3.99 vs. sHR 1.80, 95% CI 1.02-3.16). Among 7-day survivors (N=457), prevalent AKI without progression had mortality similar to no AKI (sHR 1.27, p=0.52), while prevalent AKI with progression carried the worst prognosis (sHR 3.34, 95% CI 1.44-7.77).
Both prevalent and incident AKI independently predict mortality in AH. Incident AKI confers equivalent risk despite lower disease severity and a distinct etiologic profile with higher rates of intrinsic renal injury. Early renal trajectory refines risk beyond baseline AKI status, where absence of progression approximates outcomes of those without AKI, while progressive AKI identifies the highest-risk subgroup.

PMID:
42748408
Bibliographic data and abstract were imported from PubMed on 17 Sep 2026.

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