Clinical-and-neurological symptoms and dynamics of certain biomarkers in the acute and remote periods of combat traumatic brain injury.

Authors

Volodymyr O Korshniak, Oleksandr R Pulyk, Mykola F Posokhov, Pawlo M Posokhov

Published in

Wiadomosci lekarskie (Warsaw, Poland : 1960). Volume 79. Issue 7. Pages 1475-1479.

Abstract

Aim: To study biochemical markers of brain tissue damage, the levels of which could be used to assess the degree of damage to the nervous tissue and predict the course and outcome of the disease.
Materials and Methods: There were 38 patients in the acute period and 33 in the remote period of MBT were examined. The patients' complaints, levels of brain-specific proteins S-100β, BDNF and inflammatory biomarkers such as interleukins IL-8 and IL-10 were studied in detail.
Results: The study of complaints showed their similarity in both the acute and remote periods, apart from an increase in the number of patients with meteorological sensitivity. An increase in S-100β levels and a decrease in BDNF levels indicate a slowdown in the rate of recovery processes in this category of patients and a deterioration in brain plasticity processes. An increase in IL-8 and IL-10 levels indicates further progression of the disease.
Conclusions: The study of these biomarkers contributes to the prognosis and course of the consequences of mine-blast trauma and the choice of therapeutic agents in treatment.

PMID:
42748295
Bibliographic data and abstract were imported from PubMed on 17 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.