Gas Phase Studies of Purine Base Analogs: Intrinsic Properties and Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase (HG(X)PRT).

Authors

Xiao Ding, Lanxin Zhang, G S M Kiruba, Jeehiun K Lee

Published in

The Journal of organic chemistry. Sep 09, 2026. Epub Sep 09, 2026.

Abstract

The gas-phase acidity and proton affinity of purine nucleobases that are found to be inactive for the enzyme Plasmodium falciparum hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (Pf HG(X)PRT) have been examined using both computational and experimental methods. These thermochemical values have not heretofore been measured and provide experimental data to benchmark the theoretical results. Pf HG(X)PRT is an antimalarial target; our gas-phase results lend insight into the Pf HG(X)PRT mechanism, providing a potential means of predicting enzyme substrate activity.

PMID:
42748396
Bibliographic data and abstract were imported from PubMed on 17 Sep 2026.

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