Tumor-Targeted Delivery Therapy Based on PLGA Nanoparticles.

Authors

Fang Wu, Yuan Gao, Yongjie Chi, Danyang Wang, Siqi Zhang, Ocean Cheung, Kai Zhao, Hongsheng Lu, Qi Chen, Yu Chen, Lianyan Wang, Yanhua Zhu

Published in

Journal of functional biomaterials. Volume 17. Issue 5. Apr 22, 2026. Epub Apr 22, 2026.

Abstract

Poly(lactic acid-lactic acid) (PLGA) has demonstrated significant application potential in tumor-targeted drug delivery systems due to its excellent biocompatibility, degradability, and multifunctionality for loading various therapeutic agents. PLGA nanoparticles (NPs) can achieve targeted delivery to tumor cells through specific surface modifications and stimulus-responsive release mechanisms, significantly enhancing drug accumulation efficiency at tumor sites while reducing toxic side effects on normal tissues. This review systematically summarizes the fundamental physicochemical properties of PLGA materials and recent advances in tumor-targeting strategies for PLGA NPs. It comprehensively elucidates research breakthroughs in PLGA-based delivery systems regarding stimulus-response mechanisms, passive targeting, active targeting, and tumor combination immunotherapy, while revealing the intrinsic logic of synergistic strategies for enhancing targeting efficiency. Finally, from the perspective of clinical translation and individualized oncology, this review conducts an in-depth assessment of the current challenges and looks forward to future research directions, aiming to provide forward-looking guidance for the development of precision nanomedicine.

PMID:
42188374
Bibliographic data and abstract were imported from PubMed on 17 Sep 2026.

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