From resistance genes to resistance states and enzymatic context-dependence in antimicrobial resistance.

Authors

Frank M Aarestrup, Saria Otani, Anne S Meyer, Thomas Bjarnsholt

Published in

Trends in microbiology. Sep 16, 2026. Epub Sep 16, 2026.

Abstract

Antimicrobial resistance is often inferred from resistance genes and susceptibility phenotypes measured under standardized conditions. We argue that for many resistance genes, resistance is better viewed as a context-dependent functional state; the same gene can produce different phenotypes depending on the local microenvironment, enzyme kinetics, antibiotic exposure, and bacterial physiology.

PMID:
42749572
Bibliographic data and abstract were imported from PubMed on 17 Sep 2026.

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