Authors
Zhilian Huang, Alexius Matthias Se Soh, Kangwei Zeng, Tun-Linn Thein, Jean-Marc Chavatte, Lin Cui, Raymond Lin, Vanessa Lim, Yew Woon Chia, Paul Anantharajah Tambyah, Nan Luo, Mark I-Cheng Chen
Published in
Journal of infection and public health. Volume 19. Issue 10. Pages 103359. Sep 09, 2026. Epub Sep 09, 2026.
Abstract
To assess associations between COVID-19 infection, Long COVID, and health-related quality of life (HR-QoL) in a prospective community serological cohort in Singapore.
Participants with mild or no infection were followed over 30 months (from August 2020). HR-QoL was measured using the SF-36 at visits 5 and 6 (December 2022-September 2023). Mixed-effects linear regression models examined associations between infection status and SF-36 domains, adjusting for sociodemographic and clinical factors, with age-time since infection interactions.
Among 1106 participants (aged 16-94 years), COVID-19 infection was associated with lower HR-QoL, with associations differing by age and time since infection. Participants aged ≥ 65 years had lower physical and mental HR-QoL, including beyond one-year post-infection. Among participants aged 16-64 years, lower HR-QoL was observed during the first 45 days after infection. Long COVID symptoms were associated with lower HR-QoL across multiple domains. Receipt of ≥ 3 mRNA vaccine doses was associated with higher physical and mental HR-QoL scores.
Post-COVID HR-QoL differed substantially by age. Older adults had lower HR-QoL across multiple domains, whereas younger participants showed lower HR-QoL primarily during the early post-infection period. Vaccination and the absence of Long COVID were associated with better HR-QoL outcomes.
PMID:
42748761
Bibliographic data and abstract were imported from PubMed on 17 Sep 2026.
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