Authors
Meng Lin, Langqing Liu, Gengyuan Cai, Sixiu Huang, Yibin Qiu, Zekai Yao, Shaoxiong Deng, Shiyuan Wang, Yiyi Liu, Donglin Ruan, Fuchen Zhou, Jiajin Wu, Zebin Zhang, Enqin Zheng, Jie Yang, Zhenfang Wu
Published in
Genome research. Sep 16, 2026. Epub Sep 16, 2026.
Abstract
Pigs are one of the most important livestock species worldwide. Although multiple high-quality reference genomes exist, reliance on a single linear reference limits the detection of structural variants (SVs) and the characterization of population-specific genetic diversity. To address this limitation, we developed SwinePan, a comprehensive and integrated multiomics database for pigs built on a graph-based pangenome framework. SwinePan incorporates a variome derived from the graph-based pangenome, covering 2,598 individuals across 35 breeds, including 185,759 SVs, 117 million SNPs, and 6.8 million indels. The database also integrates transcriptomic data from liver, loin muscle, abdominal fat, and backfat, along with over 150,000 phenotypic records. The online toolkit deployed in SwinePan enables genome-wide association studies (GWAS), expression quantitative trait locus (eQTL) mapping, and colocalization, while interactive modules visualize population structure and multiomics associations, streamlining candidate gene and variant exploration. Additionally, two proof-of-concept analyses demonstrate how SwinePan pinpoints trait-associated loci and deciphers their potential regulatory mechanisms.
PMID:
42749490
Bibliographic data and abstract were imported from PubMed on 17 Sep 2026.
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