[Sex-specific lithium management and perinatal specificities].

Authors

Myrto Papapanagou Chroni, Georgios Ydraios, Rayan Nasserdine, Stergios Tsartsalis, Hélène Richard-Lepouriel

Published in

Revue medicale suisse. Volume 22. Issue 975. Pages 1489-1492. Sep 16, 2026.

Abstract

Women require lower lithium doses than men and have an increased risk of renal and thyroid adverse effects. During pregnancy, lithium clearance progressively increases by 30 to 50 %, requiring frequent dose adjustments to maintain therapeutic serum concentrations between 0.6 and 1.0 mmol/l. Lithium is associated with a moderate increase in the risk of congenital malformations (odds ratio: 1.75-1.81), particularly cardiac malformations. Nevertheless, the absolute risk remains low. Close monitoring of serum concentrations is essential during pregnancy and the postpartum period, which is associated with a high risk of relapse. Breastfeeding while taking lithium remains controversial and requires individualized assessment.

PMID:
42750579
Bibliographic data and abstract were imported from PubMed on 17 Sep 2026.

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