[Detection of anti-Di^a antibody in patients with cervical space-occupying lesions following massive blood transfusion].

Authors

Ying Li, Yang Chen, Chen Wang, Lin Yang, Shiming Yang, Longfei Yang

Published in

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. Volume 42. Issue 9. Pages 808-812.

Abstract

Objective To analyze the identification of serum anti-Di^a in a patient with cervical space-occupying lesion following massive transfusion, and summarize clinical nursing measures for blood transfusion. Methods The specificity of irregular antibodies in the patient's blood type and serum was confirmed through blood type identification, irregular antibody screening and specificity identification, identification of corresponding blood type antigens and absorption and release test verification, direct immunoglobulin test (DAT) and other blood type serological testing methods. Resluts The patient's ABO blood type is type A, Rh blood type phenotype is CcDEe, and DAT is negative. There is the IgG-type anti-Di^a in the patient's serum, with an antibody titer of 1:16 and an agglutination strength of 2+. Conclusion The presence of anti-Di^a in patient's serum is the main cause of positive antibody screening and cross matching mismatch. Performing irregular antibody screening, specificity identification, and cross matching tests on patients before blood transfusion, and then selecting blood units with negative homologous blood group antigens for transfusion is an important monitoring measure to prevent hemolytic transfusion reactions.

PMID:
42750329
Bibliographic data and abstract were imported from PubMed on 17 Sep 2026.

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