The chick embryo chorioallantoic membrane as an in vivo assay to study the skin in melanoma and other skin pathological conditions.

Authors

Domenico Ribatti, Roberto Tamma

Published in

Internal and emergency medicine. Sep 17, 2026. Epub Sep 17, 2026.

Abstract

The chick chorioallantoic membrane (CAM) is a well-established model for studying angiogenesis, tumor growth, tissue grafting, and therapeutic responses; however, conventional in ovo approaches are limited by a short experimental window, immune-related constraints, and restricted imaging accessibility. Being naturally immunodeficient, the chick embryo accepts transplantation from various tissues and species. This article analyzes the literature data concerning the use of the CAM model to study melanoma and other skin pathological conditions, due to the lack of literature data summarizing this topic.

PMID:
42753094
Bibliographic data and abstract were imported from PubMed on 18 Sep 2026.

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