Wetland virus exposes blind spots in orthonairovirus pathogenesis.

Authors

Jian-Wei Shao, Xue-Lian Zhang, Xin Yin

Published in

Trends in microbiology. Sep 17, 2026. Epub Sep 17, 2026.

Abstract

Newly recognized human-associated orthonairoviruses are emerging across East Asia, yet their pathogenic mechanisms remain poorly defined. Wang et al. reveal how Wetland virus converges on caspase-3-gasdermin E pyroptosis and fatty acid synthase-dependent hepatic lipid accumulation, linking cell death to metabolic injury and exposing major gaps in pathogenesis and host-directed therapy.

PMID:
42754483
Bibliographic data and abstract were imported from PubMed on 18 Sep 2026.

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