Authors
Orkun Ilgen, Volkan Karatasli
Published in
Journal of minimally invasive gynecology. Sep 17, 2026. Epub Sep 17, 2026.
Abstract
To demonstrate extraperitoneal pelvic and para-aortic lymphadenectomy for endometrial cancer staging using vaginal natural orifice transluminal endoscopic surgery (vNOTES).
Minimally invasive surgery is widely used for endometrial cancer staging (1,2). vNOTES is a scarless minimally invasive approach, although its oncologic role remains under investigation (3). This video demonstrates extraperitoneal vNOTES pelvic and para-aortic lymphadenectomy in 11 steps, with diagrams clarifying transvaginal entry, retroperitoneal orientation, and para-aortic dissection.
A 64-year-old woman with grade 2 endometrioid endometrial carcinoma and suspicious pelvic and para-aortic lymph nodes on preoperative positron emission tomography-computed tomography.
Total hysterectomy, bilateral salpingo-oophorectomy, and extraperitoneal pelvic and para-aortic lymphadenectomy were performed using vNOTES (Figure 1). Blue dye was injected into the cervix for sentinel lymph node mapping; however, no stained sentinel lymph nodes were identified. Retroperitoneal access was obtained through the right lateral fornix into the extraperitoneal parametrial space. The paravesical and pararectal spaces were developed, followed by pelvic lymphadenectomy and para-aortic lymphadenectomy up to the renal vein (Figures 2 and 3). This route allowed direct caudal-to-cranial access with minimal bowel interference and no abdominal incision, offering improved exposure, reduced abdominal wall trauma, less postoperative pain, and scarless surgery (4). Potential disadvantages include a steep learning curve, limited working space, instrument collision, and difficulty managing major vascular injury; therefore, emergency preparedness and appropriate surgical expertise are essential. The procedure was completed without complications, and the patient was discharged on postoperative day 2. Pathology showed a 3-cm grade 2 endometrioid carcinoma with less than half myometrial invasion. A total of 12 pelvic and 8 para-aortic lymph nodes were removed.
This video illustrates the feasibility of extraperitoneal pelvic and para-aortic lymphadenectomy via vNOTES in a selected patient. Adequate lymph node yield was achieved, but comparative studies are needed before conclusions regarding equivalence or non-inferiority to laparoscopy can be drawn. With further experience, extraperitoneal vNOTES may have future applications in selected gynecologic oncologic staging procedures.
PMID:
42754009
Bibliographic data and abstract were imported from PubMed on 18 Sep 2026.
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