Telomeres in mitosis: organization and dynamics.

Authors

Mattia La Torre, Serena Fabiano, Romina Burla, Isabella Saggio

Published in

Nucleus (Austin, Tex.). Volume 17. Issue 1. Pages 2698214. Dec 31, 2026. Epub Sep 18, 2026.

Abstract

Telomeres are specialized chromosomal structures that protect chromosome ends and maintain genome stability. Their organization depends on telomeric DNA repeats, the shelterin complex, accessory factors, and telomerase. While telomere structure and maintenance have been characterized, their dynamics during mammalian mitosis remain incompletely understood. Mitosis involves profound cellular reorganization, including chromatin condensation, spindle formation, and nuclear membrane disassembly and reassembly. Emerging evidence suggests that telomeres participate in these processes and may contribute to proper chromosome segregation and post-mitotic chromatin organization. Studies indicate that telomeric proteins such as TRF1 and TNKS1 interact with centrosomes and spindle components, while telomeres also interface with chromatin and nuclear membrane reassembly factors, including BAF1, LAP2α, and the ESCRT machinery during late mitosis. Defects in these processes or interactions can lead to telomere dysfunction and genomic instability. Understanding telomere dynamics during mitosis is therefore critical for elucidating mechanisms underlying aging, laminopathies, and other telomere-related human diseases.

PMID:
42758105
Bibliographic data and abstract were imported from PubMed on 18 Sep 2026.

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