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Total synthesis of kasichelins A and B.

Created on 18 Sep 2026

Authors

Yu-Qin Tang, Xue-Hua Huang, Xin-Yi Tong, Ye Liang, Jia-Lei Yan, Ai-Jun Ma

Published in

Organic & biomolecular chemistry. Sep 18, 2026. Epub Sep 18, 2026.

Abstract

The first total synthesis of kasichelins A and B was accomplished in a concise manner via a longest linear sequence of seven steps with 25% and 18% overall yields, respectively. The synthetic route featured a judicious choice of protecting groups, a molybdenum-promoted dehydrative cyclization for construction of the dihydrooxazole core, and a convergent fragment assembly strategy to forge the complete molecular scaffold.

PMID:
42758140
Bibliographic data and abstract were imported from PubMed on 18 Sep 2026.

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