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New treatments for treatment-resistant depression: esketamine controversies - a narrative review.

Created on 18 Sep 2026

Authors

Maj Vinberg

Published in

Danish medical journal. Volume 73. Issue 9. Aug 04, 2026. Epub Aug 04, 2026.

Abstract

This narrative review examines barriers to Danish patients' timely access to new treatments for treatment-resistant depression, focusing on controversies around esketamine. Delays arise from regulatory complexity, economic constraints and scientific debate over novel psychotropics. The review advocates evidence-based, faster implementation pathways for new treatments to alleviate the overall individual and societal burden from severe depression in Denmark.

PMID:
42757607
Bibliographic data and abstract were imported from PubMed on 18 Sep 2026.

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