Authors
Yingying Wang, Wenbo Liu, Zhiran Yang, Jianlei Geng, Nan Jia, Xiaoxiao Wang, Buyun Song, Yong Li, Liwei Yang, Bibo Tan
Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Volume 40. Issue 18. Pages e72290. Sep 30, 2026.
Abstract
Cancer-associated fibroblasts (CAFs) are pivotal stromal component in tumor microenvironment (TME) and participate in regulating tumor development and progression via exosomes (exos) mediated intercommunication. However, the intricate mechanism underlying the exosomal miRNAs from CAFs in gastric cancer (GC) tumorigenesis remains ambiguous. Herein, we found that miR-4435 was highly expressed in both CAFs- derived exos and GC tissues and was associated with TNM stage as well as tumor size in GC patients. Additionally, inhibition of miR-4435 remarkably restricted GC proliferation, migration, and invasion in vitro and in vivo; whereas facilitating ferroptosis in GC cells. Moreover, miR-4435 could bind with the downstream target NDUFA10 mRNA and was shown to silence NDUFA10 expression. Importantly, exosomal miR-4435 derived from CAFs could suppress CD8+ T cells effector function, contributing to immune resistance, while knockdown of miR-4435 in CAFs-exo could foster CD8+ T cells effector function and enhanced the sensitivity of anti-PD-1 therapy in GC. Collectively, exosomal miR-4435 derived from CAFs suppress ferroptosis and CD8+ T cell effector function in GC via mediating NDUFA10. Our results highlight exos-transfered miR-4435 as a potential therapeutic target in GC.
PMID:
42760918
Bibliographic data and abstract were imported from PubMed on 19 Sep 2026.
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