Meta-analysis of PAX1/JAM3 methylation performance in high-risk HPV-positive women.

Authors

Lianxing Qi, Yinfang Wu, Minxia Luo

Published in

Medicine. Volume 105. Issue 38. Pages e50757. Sep 18, 2026.

Abstract

DNA methylation is an emerging biomarker for cervical cancer screening. This study aimed to evaluate the diagnostic performance of paired box gene 1/junctional adhesion molecule 3 (JAM3) dual-gene methylation analysis for detecting high-grade cervical intraepithelial neoplasia and cervical cancer, and to explore its potential utility as a triage biomarker for high-risk human papillomavirus positive women.
A systematic search was conducted across 5 databases, including PubMed, for studies on PAX1/JAM3 methylation testing in cervical cancer screening. Following quality assessment via the QUADAS-2 tool, statistical analyses were performed using Meta-Disc 1.4 and Stata 17 software.
Eight studies involving 7494 participants were included in the meta-analysis. For diagnosing cervical intraepithelial neoplasia grade 2 and above the pooled sensitivity was 0.81 (95% CI: 0.73-0.88), specificity was 0.95 (95% CI: 0.94-0.96), and the area under the curve was 0.96. For diagnosing cervical intraepithelial neoplasia grade 3 and above the pooled sensitivity was 0.85 (95% CI: 0.75-0.92), specificity was 0.88 (95% CI: 0.86-0.89), and the area under the curve was 0.90.
PAX1/JAM3 dual-gene methylation testing demonstrates high diagnostic accuracy for detecting high-grade cervical intraepithelial neoplasia and cervical cancer, supporting its potential role as a triage biomarker in high-risk human papillomavirus positive women.

PMID:
42760652
Bibliographic data and abstract were imported from PubMed on 19 Sep 2026.

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