Authors
Seeta Dewali, Netra Pal Sharma, Pankaj Bhatt, Neha Kathayat, Megha Bhandari, Deepak Chandra Melkani, Deepika Goswami, Suraj Suraj, Deepak Kumar Arya, Swetapadma Dash, Harish Chandra Singh Bisht, Satpal Singh Bisht
Published in
Biomaterials translational. Volume 7. Issue 2. Pages 275-298. Epub Sep 11, 2025.
Abstract
Biomaterials are engineered substances designed to interact with biological systems for therapeutic or diagnostic purposes. Their inherent properties-including biocompatibility, biodegradability, and structural versatility-have driven major advancements in drug delivery technologies. The global biomaterials market size was estimated at USD 178.0 billion in 2023 and is projected to grow at a compound annual growth rate of 15.6% from 2024 to 2030. The growing incidence of musculoskeletal and chronic skeletal disorders is expected to drive demand for biomaterial-based implants, thereby contributing to market expansion. This review critically examines biomaterials, focusing on their classification into biobased, biodegradable, and biocompatible categories and analyzes their physicochemical properties and functional benefits. It highlights their applications in oncology, cardiovascular therapy, neurodegenerative diseases, and vaccination. Key challenges-including immunogenicity, cytotoxicity, and manufacturing complexities-are discussed, emphasizing the need for rigorous evaluation and adaptive regulatory frameworks. The review also explores recent advances in smart biomaterials for precision drug delivery, underscoring their potential to revolutionize personalized medicine through targeted, efficient, and patient-specific therapies.
PMID:
42760964
Bibliographic data and abstract were imported from PubMed on 19 Sep 2026.
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