Authors
Eduardo Egea-Bermejo, Luis Fang, Carlos Octavio Arroyo-Movilla, Alex Domínguez-Vargas, Ana Moreno-Woo, Gloria Garavito De Egea
Published in
Allergologia et immunopathologia. Volume 54. Issue 5. Pages 10-17. Epub Sep 01, 2026.
Abstract
Chronic spontaneous urticaria (CSU) is a systemic immune-mediated disorder frequently comorbid with autoimmune thyroid disease, particularly Hashimoto's thyroiditis (HT). Emerging evidence implicates shared immunogenetic pathways, yet the role of thymic stromal lymphopoietin (TSLP), a key epithelial alarmin in this comorbidity remains unclear.
To investigate the association between TSLP SNPs and the co-occurrence of CSU and HT.
We enrolled 45 patients with CSU alone and 41 with CSU and concomitant HT from a reference center in the Colombian Caribbean. Diagnosis of HT was based on clinical, ultrasonographic, serological (anti-TPO >35 IU/mL), and biochemical criteria. Genotyping of TSLP SNPs rs1837253, rs2289276, and rs17551370 was performed using TaqMan® assays.
The rs17551370 GG genotype was significantly more prevalent in the CSU+HT group (88% vs. 71%; OR = 3.84, 95% CI: 1.21-12.2; p = 0.02). Conversely, the rs2289276 TT genotype was less frequent in the CSU+HT group (2.4% vs. 18%; OR = 0.11, 95% CI: 0.02-0.74; p = 0.02), suggesting a protective effect. Carriers of the CCG haplotype (Ht1) exhibited a 2.11-fold increased odds of presenting concomitant HT among patients with CSU (OR = 2.11; 95% CI: 1.11-4.01; p = 0.02).
TSLP promoter variants rs17551370 and rs2289276 are significantly associated with CSU-HT comorbidity, supporting a shared pathogenic mechanism driven by dysregulated alarmin signaling and Th2/Th17 inflammation. These findings highlight TSLP as a potential genetic marker and therapeutic target in autoimmune urticaria.
PMID:
42760875
Bibliographic data and abstract were imported from PubMed on 19 Sep 2026.
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