Authors
Xing Jin, Jia Li, Yuanqi Zhao, Kun Xu, Yuge Wang, Song Bai, Yashu Liu, Zhenhua Li
Published in
Frontiers in nutrition. Volume 13. Pages 1893492. Epub Sep 04, 2026.
Abstract
Nephrolithiasis represents a substantial clinical burden worldwide. The Dietary Index for Gut Microbiota (DI-GM) assesses dietary impacts on gut microbiota. However, its association with the risk of nephrolithiasis remains unclear in Chinese adults.
We conducted a case-control study using the Shenyang sub-cohort of the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) cohort. Cases were 278 patients with nephrolithiasis. Controls were 556 healthy individuals, matched 1:2 by age and sex. Dietary intake was assessed using a validated food frequency questionnaire (FFQ) to calculate DI-GM scores. Multivariable conditional logistic regression evaluated the association. Restricted cubic spline (RCS) explored non-linear associations, and subgroup analyses were stratified by age and sex.
Higher DI-GM scores were significantly associated with lower risk of nephrolithiasis. After adjustment, the risk decreased progressively with increasing DI-GM scores (P for trend < 0.05). Individuals with DI-GM ≥ 8 had 83% lower risk than those scoring 0-5 (odds ratio [OR] = 0.17, 95% confidence interval [CI]: 0.08-0.36). The association was consistent across age and sex subgroups, with no non-linearity (P for non-linearity > 0.05).
In Chinese adults, higher adherence to the DI-GM was associated with lower risk of nephrolithiasis. This finding suggests gut-friendly dietary patterns may be associated with a lower likelihood of nephrolithiasis. Future prospective studies are warranted to confirm this association.
PMID:
42761072
Bibliographic data and abstract were imported from PubMed on 19 Sep 2026.
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