Designing artificial cofactors and their enzymes together.

Authors

Alexandra P Platt, Yannick J Bomble, Robert S Paton

Published in

Trends in biotechnology. Sep 19, 2026. Epub Sep 19, 2026.

Abstract

When replacing expensive redox cofactors, making biomimetic cofactors with desirable thermostability and redox properties is only half of the equation; enzymes must also be able to use them. Ji and colleagues confront that trade-off by pairing the development of a thermostable carbocyclic cofactor with a dedicated regeneration enzyme for sustained biocatalysis.

PMID:
42763265
Bibliographic data and abstract were imported from PubMed on 20 Sep 2026.

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