Authors
Francesco Givigliano, Teresa Ferrazzo, Filippo Lococo, Paolo Mendogni, Ottorino Perrone, Salvatore Merola, Valeria Manfredi, Mary Jo Filice, Massimiliano Tisba, Giancarlo Pino, Marco Chiappetta
Published in
Mediastinum (Hong Kong, China). Volume 10. Pages 33. Epub Aug 25, 2026.
Abstract
Thymic epithelial tumors (TETs) present peculiar characteristics, with indolent behavior and excellent prognosis when treated. Based on these characteristics, also recurrence may present similar characteristics, but some aspects of their management should be interpreted and are still not well defined. The objective of this narrative review is to discuss peculiar aspects of primary and recurrent TETs showing how should be managed.
A literature search was conducted using PubMed and Google Scholar to inform the narrative review. Eligible articles had to be published in English between January 1, 1991 to September 30, 2025.
The presentation of recurrent disease may show some differences compared with primary tumors. Many features are shared by primary TETs and their recurrences, with only limited changes in histology and genetic profiles that do not seem to significantly affect prognosis. Recurrences generally retain the characteristics of the original tumor, although they may exhibit greater clinical aggressiveness. Due to their clinically indolent behavior, these tumors are managed quite peculiarly. Indeed, surgery represents the cornerstone of treatment for these tumors and is often considered, even in cases of recurrence.
Primary TETs and recurrences present similar characteristics that may be considered during treatment, even if in case of recurrence the more aggressive behavior should be taken into account.
PMID:
42763624
Bibliographic data and abstract were imported from PubMed on 20 Sep 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 16
- Comments 0