Current Management and Investigational Therapeutic Strategies in Penile Squamous Cell Carcinoma: A Narrative Review.

Authors

Lorenzo Lobianco, Gabriele Calvanese, Chiara D'Alessio, Francesco Passaro, Anna Passarelli, Jole Ventriglia, Sabrina Chiara Cecere, Sabrina Rossetti, Carmela Pisano, Rosa Tambaro, Marilena Di Napoli, Roberto Contieri, Achille Aveta, Erica Perri, Giovanni Pacifico, Maria Rosaria Lamia, Elisabetta Coppola, Luca Tarotto, Florinda Feroce, Filippo Sepe, Gabriel Perasole, Teresa Troiani, Sandro Pignata

Published in

Critical reviews in oncology/hematology. Pages 105608. Sep 20, 2026. Epub Sep 20, 2026.

Abstract

Penile squamous cell carcinoma (PSCC) is a rare and aggressive genitourinary malignancy requiring integrated multidisciplinary management. This narrative review provides an updated overview of the diagnostic and therapeutic pathway of PSCC from localized disease, where surgery remains the cornerstone of treatment, to locally advanced disease, where multimodal strategies integrating chemotherapy and radiotherapy with surgery are required, and finally to metastatic disease, where systemic therapy becomes the mainstay of treatment. Platinum-based chemotherapy remains the established systemic backbone for advanced PSCC, whereas immune checkpoint inhibitors, chemo-immunotherapy combinations, targeted therapies, antibody-drug conjugates, vaccines, and adoptive cellular therapies represent investigational strategies supported by preliminary evidence. Although these approaches have shown early signals of activity, their routine integration into clinical practice remains limited by small and heterogeneous studies, the lack of definitive randomized evidence, and the need for prospective validation in well-defined clinical and molecular subgroups. The aim of this review is therefore to provide a stage-adapted and multidisciplinary overview of therapeutic strategies for the contemporary management of PSCC.

PMID:
42764099
Bibliographic data and abstract were imported from PubMed on 21 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.