Association of B-Type Natriuretic Peptide With Intrinsic Capacity Trajectories Among Chinese Older Adults.

Authors

Na Zhang, Xichenhui Qiu, Xiaofeng Wang, Ling Wei, Xinyuan Li, Shuanglin Xie, Chunlai Zeng, Xiaoyan Jiang

Published in

Journal of the American Geriatrics Society. Sep 20, 2026. Epub Sep 20, 2026.

Abstract

Intrinsic capacity (IC) is central to healthy aging, yet accessible and cost-effective biomarkers for identifying individuals at risk of IC decline remain limited. We investigated whether elevated B-type natriuretic peptide (BNP), including persistent BNP abnormalities, is associated with baseline IC and longitudinal IC decline.
We conducted a population-based prospective cohort study using data from the Rugao Longevity and Aging Study, which included three waves of assessments over 4 years. IC was quantified as a composite score across five domains-mobility, vitality, cognition, psychological, and sensory-and assessed at baseline and follow-up visits. Longitudinal associations between BNP levels (quartiles, binary elevation, and cumulative abnormalities) and changes in IC were analyzed using generalized estimating equations.
Among 1494 participants (mean [SD] age 77.9 [4.5] years, 46.4% male), higher BNP levels were significantly associated with lower IC scores at baseline (adjusted β = -0.46, 95% CI: -0.70, -0.22). In a longitudinal analysis, compared with the lowest quartile, the highest BNP quartile was associated with greater IC decline (adjusted β = -0.43; 95% CI: -0.70, -0.19). Elevated BNP was similarly associated with IC decline (adjusted β = -0.37; 95% CI: -0.57, -0.18). Findings remained significant among participants without CVD. Persistent BNP elevation at baseline and 2-year follow-up was associated with subsequent IC decline (adjusted β = -0.36; 95% CI: -0.65, -0.06).
Elevated and persistent BNP abnormalities are consistently associated with IC decline, supporting BNP as a practical biomarker for early identification of older adults at risk of functional deterioration.

PMID:
42764591
Bibliographic data and abstract were imported from PubMed on 21 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.