The Effect of rs7975232 (ApaI) and rs731236 (TaqI) VDR Polymorphisms on HIV/AIDS Prevalence and Mortality: An International Population Genetics Analysis.

Authors

Nermin Akcali, Cüneyd Yavas, Sajjad Eslamkhah, Sonat Sina Canturk, Kevser Eryildiz, Nisa Aslan, Zeynep Nur Ozcan, Lutfiye Karcioglu Batur

Published in

AIDS research and human retroviruses. Pages 8892229261487810. Sep 20, 2026. Epub Sep 20, 2026.

Abstract

In this study, the relationship between the allele and genotype frequencies of the rs7975232 (ApaI) and rs731236 (TaqI) polymorphisms of the vitamin D receptor (VDR) gene and country-based HIV/AIDS prevalence and mortality rates were examined using Spearman rank correlation analyses. These Spearman analyses were validated for significance using the False Discovery Rate (FDR) method, considering traditional criteria (Adjusted p-value <.05). The findings revealed that ApaI_CC and TaqI_TT genotype frequencies showed weak inverse correlations with HIV/AIDS prevalence and mortality rates (ρ ≈ -0.30 and -0.25); however, these correlations were not statistically significant after FDR correction (p_adj > 0.05). These results suggest that VDR polymorphisms showed no statistically significant association with HIV/AIDS epidemiology in this ecological analysis; at most, these findings generate a population-level hypothesis that vitamin D-mediated immune responses may warrant further study. These findings should be regarded as exploratory and hypothesis-generating, and may inform future individual-level genotype-phenotype and functional studies.

PMID:
42764510
Bibliographic data and abstract were imported from PubMed on 21 Sep 2026.

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