Analysis of Complications Associated with Basivertebral Nerve Ablation for Vertebrogenic Low Back Pain: A Multicenter Retrospective Cohort Study of 1,145 Patients.

Authors

Bryan C Hoelzer, Acelan Obray, Ramana Naidu, Amanda N Cooper, Zachary L McCormick, Napatpaphan Kanjanapanang, Greg Moore, Yeng F Her, Thomas P Pittelkow, Oludare Olatoye, Eric Freeman, Mikayla Parker, Ellie A Mitchell, Lucas Peterson, Bryson Childs, Erik Eckstrom, Petra V Ekstrom, Lindsey A Haugen, Ashley L Hamann, Grace G Carson, Alyssa S Mayeri, Candance M Peterson, Hayden E Fortin

Published in

Pain medicine (Malden, Mass.). Sep 19, 2026. Epub Sep 19, 2026.

Abstract

Low back pain (LBP) is a leading cause of pain and disability worldwide. Recent studies demonstrate a vertebrogenic model involving the basivertebral nerve (BVN) as a cause of chronic LBP. Vertebral endplates are highly innervated by the BVN, and literature shows type 1 and 2 Modic changes at vertebral endplates are a source of vertebrogenic low back pain (VBP). As a result, intraosseous radiofrequency ablation of the BVN is a minimally invasive outpatient procedure used to treat VBP. We conducted a retrospective review of 1,145 patients that have undergone BVN ablation to assess for safety and complication management.
Chart reviews were conducted to obtain demographic and pre-procedural information regarding patient gender, age at the time of BVN ablation, duration of LBP, and BMI. Post-procedure information derived from chart notes included vertebral levels ablated and post-BVN ablation complications, which were categorized as increased LBP > 7 days, increased radicular pain > 7 days, lower extremity weakness, infection, vertebral compression fracture, superficial bleeding, spinal or epidural hematoma, serious neurological injury, visit to the ER, and deep vein thrombosis/clot.
1,145 patient charts were reviewed showing an overall complication rate of 3.2% (37 complications). Increased radicular pain was the most common complication at 2.2% (25 complications) and resolved completely in all but one patient. The overall complication rate fell to 1.1% (13 complications) when the 24 cases of transient radicular pain were not counted as adverse events.
In this multicenter retrospective review, the overall rate of complications related to BVN ablation was low (3.2%). The most common complication was temporary radicular pain that resolved with conservative care. These findings suggest that BVN ablation is a safe treatment for VBP in real-world clinical settings.

PMID:
42765343
Bibliographic data and abstract were imported from PubMed on 21 Sep 2026.

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