Protocol for repeated Plasmodium chabaudi infection in a murine malaria model.

Authors

Federica Bruno, Jean Langhorne, Cristina Lo Celso

Published in

STAR protocols. Volume 7. Issue 4. Pages 104850. Sep 21, 2026. Epub Sep 21, 2026.

Abstract

In malaria-endemic regions, individuals experience repeated malaria infection throughout life. Here, we present a protocol to investigate the immunological mechanisms triggered by repeated exposure using a murine model of sequential infections with the rodent parasite Plasmodium chabaudi chabaudi. We provide a detailed and standardized series of steps covering primary infection, natural recovery without treatment, and subsequent secondary infection. This approach offers a robust framework to investigate the effects and long-term consequences of repeated malaria infections on the host. For complete details on use and execution of this protocol, please refer to Stephen et al.,¹ Pérez-Mazliah et al.,² and Achtman et al.³.

PMID:
42766410
Bibliographic data and abstract were imported from PubMed on 22 Sep 2026.

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