Erinacerins from Hericium erinaceus: a review of their chemistry, bioactivities, and NMR characterization.

Authors

Ahmed Othman, Yhiya Amen, Kuniyoshi Shimizu

Published in

Journal of natural medicines. Sep 21, 2026. Epub Sep 21, 2026.

Abstract

The medicinal mushroom Hericium erinaceus is a rich source of diverse bioactive secondary metabolites. Erinacerins are a significant class of structurally diverse secondary metabolites, comprising both nitrogen-containing alkaloids bearing an isoindolinone or pyridinone core and non-nitrogenous congeners. This review provides a comprehensive overview of 28 known erinacerins reported from H. erinaceus, detailing their isolation, structural elucidation, and diverse bioactivities. A key focus is directed toward their characterization by NMR spectroscopy, offering a systematic guide for the identification of this class of molecules. The discussion encompasses the reported inhibitory effects of erinacerins against enzymes such as acetylcholinesterase and α-glucosidase, as well as their anti-inflammatory and cytotoxic activities against various cancer cell lines, underscoring their pharmacological potential. This work highlights the significance of erinacerins as a valuable scaffold of bioactive metabolites for therapeutic applications.

PMID:
42766259
Bibliographic data and abstract were imported from PubMed on 22 Sep 2026.

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