[The role of thrombomodulin in pulmonary hypertension associated with bronchopulmonary dysplasia in preterm infants].

Authors

L Gassiat, I Gauthereau, G Cardouat, P Robillard, C M Pilard, B Pere, E Dumas-De-La-Roque, F Sauvestre, F Pelluard, S Berenguer, L Sentilhes, F Coatleven, M Vincienne, P Berger, C Guibert

Published in

Revue des maladies respiratoires. Sep 21, 2026. Epub Sep 21, 2026.

Abstract

Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease in premature newborns born before 32 weeks of gestation. It is characterized by arrested lung growth (hypoalveolarization), rarefaction of microvascularisation (hypoangiogenesis), and inflammation. BPD can be complicated by pulmonary hypertension (PH-BPD), which increases the mortality rate by nearly 50% within two years after diagnosis. Thrombomodulin is a glycoprotein mainly expressed on vascular endothelial cells. It plays a central role in hemostasis, but also contributes to inflammation and angiogenesis and is used as a biomarker in certain cardiopulmonary pathologies. Deregulation of its expression may therefore play an important role in the development of inflammatory diseases and/or angiogenesis defects, such as PH-BPD.

PMID:
42767899
Bibliographic data and abstract were imported from PubMed on 22 Sep 2026.

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