Systemic light chain amyloidosis presenting as jejunal perforation.

Authors

Hung-Chih Chen, Ta-Chuan Yu, Keng-Man Chiang, Shang-Yi Huang

Published in

BMJ case reports. Volume 19. Issue 9. Sep 21, 2026. Epub Sep 21, 2026.

Abstract

Systemic light chain (AL) amyloidosis is a clonal plasma cell dyscrasia characterised by extracellular deposition of misfolded amyloid fibrils composed of immunoglobulin light chains. These amyloid fibrils disrupt tissue architecture, ultimately leading to organ dysfunction. Clinical symptoms vary among cases, depending on the organs involved. The heart and kidney are the most commonly affected vital organs, whereas jejunal involvement is rare.We report a case of jejunal perforation associated with systemic AL amyloidosis during treatment of recurrent uterine cancer. The deposition of amyloid fibrils has also been identified in uterine cancer tissue specimens. Tracing back to her history, postprandial abdominal distension developed 3 years before jejunal perforation. This case highlights both the chronic and acute gastrointestinal manifestations of AL amyloidosis; however, diagnosis and treatment remain challenging in patients with such complex comorbidities.

PMID:
42767783
Bibliographic data and abstract were imported from PubMed on 22 Sep 2026.

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