Authors
Joana Neves, Pedro Sousa-Victor, Pura Muñoz-Cánoves
Published in
Cold Spring Harbor perspectives in biology. Sep 21, 2026. Epub Sep 21, 2026.
Abstract
Stem cells are central for tissue homeostasis and regeneration after stress, and their function depends on interactions with neighboring niche cells. In skeletal muscle, the resident stem cells (also called satellite cells [SCs]) decline in number and function with age, leading to loss of regenerative capacity and, eventually, deterioration of muscle integrity and physiology. Aged SCs lose the capacity to preserve quiescence or to activate and expand upon injury, in part due to changes in the local and systemic environment. Here, we focus on the age-associated intrinsic changes of SCs and the causes of their cellular and molecular decline. We discuss results from single-cell omics technologies that have shed light on the interactions between SCs and niche cells and how far-reaching signals impact SC function. We present future perspectives on rejuvenating interventions to counter age-dependent regenerative decline and the open questions in muscle stem cell aging.
PMID:
42767774
Bibliographic data and abstract were imported from PubMed on 22 Sep 2026.
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