Authors
Aijing Wang, Shili Ai, Yilin Song, Yuhan Wang, Qi Zhang, Xinyuan Feng, Xiaozhong Qu, Bing Han, Xiaoyan Wang
Published in
Advanced materials (Deerfield Beach, Fla.). Pages e75042. Sep 22, 2026. Epub Sep 22, 2026.
Abstract
Periodontitis, the sixth most prevalent global disease, causes tooth loss and systemic disorders, imposing a significant global burden. Functional regeneration of the periodontium remains a major challenge due to the hierarchical soft-hard tissue interface and complex spatiotemporal functional demands. In this study, a synchronously in situ co-injectable, interlayer-bonding, and wet-adhesive bilayer hydrogel (Bio-Fun bilayer) consisting of PCAC and PCMC layers is developed. An anti-delamination interface is engineered via polymer chain topological entanglement and dynamic boronate ester and ionic networks, while precise complex viscosity matching enables synchronized microscale laminar co-extrusion. Concurrently, the hydrogel maintains wet adhesion, especially to moist root and bone surfaces. Spatiotemporal biofunctionalization is achieved by loading microRNA-26a liposomes in the PCAC layer to activate Wnt/β-catenin signaling for osteogenesis, and covalently tethering a PDGF-BB mimetic peptide within the PCMC layer to trigger PI3K/Akt-LOX signaling for fibroblast recruitment and functional collagen formation. In vivo, the Bio-Fun bilayer hydrogel achieves integrated regeneration of alveolar bone and aligned periodontal ligament fibers, forming Sharpey's fiber-like structures with firm bone-ligament attachment. Meanwhile, the modular and injectable design might provide broad reference for the reconstruction of periodontal, osteochondral, and other soft-hard tissue interfaces.
PMID:
42768922
Bibliographic data and abstract were imported from PubMed on 22 Sep 2026.
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